Organic Acids Test (OAT)

The Organic Acids Test (OAT) from Mosaic Diagnostics is available at Toronto Centre for Naturopathic Medicine.

The Organic Acids Test (OAT) is a comprehensive urine-based assessment that provides insight into key metabolic processes occurring at the cellular level. By measuring 76 organic acid metabolites, this test helps identify functional imbalances related to gut microbial overgrowth, mitochondrial energy production, neurotransmitter metabolism, nutrient status, and detoxification pathways.

The Organic Acids Test (OAT) is widely used by naturopathic doctors and integrative and functional medicine practitioners to gain detailed information that standard blood tests do not assess in patients suffering from chronic digestive symptoms, unexplained fatigue, chronic pain, anxiety or depressive symptoms, and other symptoms of cognitive function such as “brain fog”.

At our Toronto Centre for Naturopathic Medicine, we use the Organic Acids Test (OAT) to uncover root causes behind complex health conditions that have proven resistant to treatment and to guide highly personalized treatment plans.

The Organic Acids Test (OAT) measures:

The Organic Acids Test (OAT) measures metabolites that reflect function in several core physiological systems, including:

  • Gut microbial overgrowths (e.g., bacterial, fungal, yeast)
  • Mitochondrial function and energy metabolism (e.g., indicators of oxidative stress)
  • Neurotransmitter metabolism (e.g., dopamine, norepinephrine, epinephrine, and serotonin metabolites)
  • Nutrient status indicators (e.g., functional markers for B-complex vitamins, glutathione status and antioxidant demand)
  • Detoxification and liver function (e.g., Phase I and Phase II detoxification by-products, environmental toxicant metabolism markers)
  • Fatty acid and carbohydrate metabolism (e.g., glycolysis and ketone metabolism indicators)
  • Oxalate metabolism

The Organic Acids Test (OAT) may provide useful guidance if:

The Organic Acids Test (OAT) may be clinically helpful if you experience symptoms without a clear underlying cause, including:

  • Chronic fatigue or low stamina
  • Brain fog, poor concentration, or memory issues
  • Mood concerns such as anxiety, low mood, or irritability
  • Digestive symptoms including bloating, gas, or irregular stools
  • Sugar cravings or difficulty tolerating carbohydrates
  • Sensitivity to supplements or medications
  • Sleep disturbances
  • Exercise intolerance or slow recovery

It may also help your naturopathic doctor understand underlying causes of:

  • Gut dysbiosis or suspected yeast overgrowth
  • Mitochondrial dysfunction
  • Nutrient insufficiencies despite adequate intake
  • Neurotransmitter imbalance
  • Chronic inflammatory or oxidative stress patterns
  • Metabolic stress associated with chronic illness

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