IgG Food Sensitivity Testing

IgG food sensitivity testing is available at Toronto Centre for Naturopathic Medicine.

IgG food sensitivity testing measures specific IgG antibodies to foods in blood to identify commonly eaten items your immune system has encountered.

It is widely used by naturopathic doctors and integrative and functional medicine practitioners to help guide dietary treatment for chronic digestive or inflammatory conditions.

What does IgG food sensitivity testing measure?

IgG food sensitivity measures the levels of immunoglobulin G (IgG) antibodies to foods. Although it is normal to have some IgG antibodies to foods to the foods you eat in your bloodstream, high levels of antibodies may be associated with clinical symptoms.

Removal of the identified foods can result in improvement of symptoms.

For example: You experience chronic joint pain. If potatoes are a part of your diet, it is expected that you will have some amount of “potato IgG” in your blood. However, if you have high levels of “potato IgG” in your blood, and you remove potatoes from your diet, your symptoms (e.g., joint pain) may improve.

IgG food sensitivity testing may provide useful guidance if you experience:

  • chronic inflammation
  • digestive symptoms
  • migraine headaches
  • skin conditions
  • joint pain
  • heart disease
  • obesity
  • mental health challenges

Research on IgG food sensitivity testing has demonstrated that is offers useful guidance in dietary treatment of:

How does IgG food sensitivity testing work?

IgG food sensitivity testing is a blood test. It requires blood sample collection, either via blood draw or dried blood spot.

“Slides” of food antigen are exposed to patients blood samples. ELISA (enzyme linked immunosorbant assay) analysis technology is used to detect and measure amounts of antibodies binding to “food antigen slides”.

IgG Food Sensitivity Testing Customization

At Toronto Centre for Naturopathic Medicine, we have access to multiple laboratories offering IgG food sensitivity testing, including:

Each laboratory offers a range of testing panel options including:

  • “Basic” panels – typically testing approximately 100 foods
  • “Expanded” panels – typically testing approximately 185 to 249 foods
  • Vegetarian panels
  • Asian food panels (US BioTek Laboratories)
  • Chinese food panels (Alletess Medical Laboratory)
  • Japanese food panels (Alletess Medical Laboratory)
  • Mexican food panels (US BioTek Laboratories)

Each laboratory offers different immunoglobulin testing combinations:

  • All IgG combined (1, 2, 3, 4)
  • IgG (1, 2, 3) separate from IgG4
  • IgG4 only
  • IgA “add-on”
  • IgE food panel “add-on”

We will help you navigate which option is appropriate for you!

References

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Zar S, Mincher L, Benson MJ, Kumar D. Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome. Scand J Gastroenterol. 2005 Jul;40(7):800-7. doi: 10.1080/00365520510015593. PMID: 16109655.

Cai C, Shen J, Zhao D, Qiao Y, Xu A, Jin S, Ran Z, Zheng Q. Serological investigation of food specific immunoglobulin G antibodies in patients with inflammatory bowel diseases. PLoS One. 2014 Nov 13;9(11):e112154. doi: 10.1371/journal.pone.0112154. PMID: 25393003; PMCID: PMC4230978.

Kakodkar S, Mutlu EA. Diet as a Therapeutic Option for Adult Inflammatory Bowel Disease. Gastroenterol Clin North Am. 2017 Dec;46(4):745-767. doi: 10.1016/j.gtc.2017.08.016. PMID: 29173519; PMCID: PMC5821251.

Alpay K, Ertas M, Orhan EK, Ustay DK, Lieners C, Baykan B. Diet restriction in migraine, based on IgG against foods: a clinical double-blind, randomised, cross-over trial. Cephalalgia. 2010 Jul;30(7):829-37. doi: 10.1177/0333102410361404. Epub 2010 Mar 10. PMID: 20647174; PMCID: PMC2899772.

Yine H, Shufang D, Bin W, Wei Q, Ashraf MA, Junling G. Application of Food-specific IgG Antibody Detection in Allergy Dermatosis. Open Med (Wars). 2015 Dec 17;10(1):377-381. doi: 10.1515/med-2015-0067. Retraction in: Open Med (Wars). 2016 Jul 8;11(1):237. doi: 10.1515/med-2016-0046. PMID: 28352722; PMCID: PMC5368854.

Ratner D, Eshel E, Vigder K. Juvenile rheumatoid arthritis and milk allergy. J R Soc Med. 1985 May;78(5):410-3. doi: 10.1177/014107688507800515. PMID: 3989811; PMCID: PMC1289727.

Wu M, Wang X, Sun L, Chen Z. Associations between food-specific IgG and health outcomes in an asymptomatic physical examination cohort. Nutr Metab (Lond). 2022 Mar 19;19(1):22. doi: 10.1186/s12986-022-00657-5. PMID: 35305694; PMCID: PMC8933923.

Karakuła-Juchnowicz H, Szachta P, Opolska A, Morylowska-Topolska J, Gałęcka M, Juchnowicz D, Krukow P, Lasik Z. The role of IgG hypersensitivity in the pathogenesis and therapy of depressive disorders. Nutr Neurosci. 2017 Feb;20(2):110-118. doi: 10.1179/1476830514Y.0000000158. Epub 2016 Mar 7. PMID: 25268936.

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